Tracie Delgado, Sarah Clark, Kelsey Furiya, Angie Vazquez, Madeleine Splattstoesser, Haleigh Schwartz, Abdullah Bashmail, Tim Nelson, Makaiya Russell, Shun-Je Bhark, Eric Owsley, Samantha Kimmel, Morgan McGovern, and Tyler Ptacek. Alteration of host cell metabolism by murine herpesvirus 68 (MHV-68) is required for infectious viral production. American Society for Virology international conference. Madison, WI. July 16-20, 2022.
Associate Professor
Biology
Poster;
https://www.biorxiv.org/content/10.1101/2023.01.30.526357v1.full
Viruses are intracellular parasites which lack their own metabolism, so they must hijack host cell metabolic machinery to create more energy, proteins, fats and genetic material necessary to replicate and create new virus particles. It is estimated that ~15% of all cancers are caused by viruses. The Delgado research lab identified the metabolic pathways that are altered by a cancer causing herpesvirus and identified that anti-metabolism drugs can be used to block virus production.